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SARS-CoV-2 Genomic Surveillance Reveals Little Spread From a Large University Campus to the Surrounding Community
- Source :
- Open Forum Infectious Diseases
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Background Coronavirus disease 2019 (COVID-19) has had high incidence rates at institutions of higher education (IHE) in the United States, but the transmission dynamics in these settings are poorly understood. It remains unclear to what extent IHE-associated outbreaks have contributed to transmission in nearby communities. Methods We implemented high-density prospective genomic surveillance to investigate these dynamics at the University of Michigan and the surrounding community during the Fall 2020 semester (August 16–November 24). We sequenced complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from 1659 individuals, including 468 students, representing 20% of cases in students and 25% of total cases in Washtenaw County over the study interval. Results Phylogenetic analysis identified >200 introductions into the student population, most of which were not related to other student cases. There were 2 prolonged student transmission clusters, of 115 and 73 individuals, that spanned multiple on-campus residences. Remarkably, Conclusions The largest outbreaks among students at the University of Michigan did not significantly contribute to the rise in community cases in Fall 2020. These results provide valuable insights into SARS-CoV-2 transmission dynamics at the regional level.
- Subjects :
- Student population
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
SARS-CoV-2
Transmission (medicine)
business.industry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
education
transmission
infection prevention
Outbreak
genomic epidemiology
Major Articles
University campus
AcademicSubjects/MED00290
Infectious Diseases
university
Oncology
Medicine
High incidence
business
Demography
Subjects
Details
- ISSN :
- 23288957
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Open Forum Infectious Diseases
- Accession number :
- edsair.doi.dedup.....bb0f8ead5ccf14cc9502f0506462ab56