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Effect of Lugol Solution on Thyroid Gland Blood Flow and Microvessel Density in the Patients with Graves’ Disease
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 92:2182-2189
- Publication Year :
- 2007
- Publisher :
- The Endocrine Society, 2007.
-
Abstract
- Context: Although some endocrine surgeons administer Lugol solution to decrease thyroid gland vascularity, there is still not an agreement on its effectiveness. Objective: The aims of this clinical trial are to evaluate thyroid blood flow and microvessel density in patients with Graves’ disease who received Lugol solution treatment preoperatively. Design: This was a prospective clinical trial. Setting: This clinical trial took place at a tertiary referral center. Method: Thirty-six patients were randomly assigned to receive either preoperative treatment with Lugol solution (group 1, n = 17) or no preoperative treatment with Lugol solution (group 2, n = 19). Main Outcome Measures: Blood flow through the thyroid arteries of patients with Graves’ disease was measured by color flow Doppler ultrasonography. The microvessel density (MVD) was assessed by immunohistochemical and Western blot analysis of the level of expression of CD-34 in thyroid tissue. The weight and blood loss of the thyroid gland were measured in all patients. Results: The mean blood flow, MVD, CD-34 expression, and blood loss in group 1 patients were significantly lower than those in group 2 patients. There was a negative correlation between Lugol solution treatment and blood flow (rs = −0.629; P = 0.0001), blood loss (rs = −0.621; P = 0.0001), MVD (rs = −0.865; P = 0.0001), and CD-34 expression (rs = −0.865; P = 0.0001). According to logistic regression analysis, Lugol solution treatment resulted in a 9.33-fold decreased rate of intraoperative blood loss. Conclusion: Preoperative Lugol solution treatment decreased the rate of blood flow, thyroid vascularity, and intraoperative blood loss during thyroidectomy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Graves' disease
medicine.medical_treatment
Blotting, Western
Clinical Biochemistry
Thyroid Gland
Hemodynamics
Antigens, CD34
Context (language use)
Biochemistry
Preoperative care
Hemostatics
Endocrinology
Internal medicine
Preoperative Care
medicine
Humans
Endocrine system
Prospective Studies
business.industry
Microcirculation
Biochemistry (medical)
Thyroid
Thyroidectomy
Ultrasonography, Doppler
Blood flow
Iodides
Middle Aged
medicine.disease
Immunohistochemistry
Graves Disease
medicine.anatomical_structure
Regional Blood Flow
Regression Analysis
Female
business
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....bb0daa3d84299eb02b6abd001660fe64