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Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
- Source :
- Volume: 35, Issue: 4 301-305, Balkan Medical Journal, Balkan Medical Journal, Vol 35, Iss 4, Pp 301-305 (2018)
- Publication Year :
- 2018
- Publisher :
- Trakya Üniversitesi, 2018.
-
Abstract
- Background: Dysmenorrhea is one of the most common acute pain disorders among women of reproductive age. Aims: To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department. Study Design: Randomized controlled trial. Methods: Patients over 18 years old presenting with pelvic pain related to menstruation were eligible for the study. Study patients received 1 g paracetamol or 50 mg dexketoprofen in 100 mL normal saline with a 4-5 minute infusion via the intravenous route. Pain intensity was measured by a visual analog scale at 15 and 30 minutes. Patients were randomized and assigned to either of two study arms via sealed envelopes. Study drugs were identical in color, and thus both personnel and patients were blinded to the study drug. The dexketoprofen group comprised 49 patients, and the paracetamol group had 50 patients in the final analysis. Results: The mean age of the study subjects was 20.9±2.5 and the mean duration of the pain was 1.9±1.7 (median: 1, interquartile range: 1 to 2) hours. Both dexketoprofen (median change: 33, 95% CI: 24 to 38) and paracetamol (median change: 21, 95% CI: 12 to 32) effectively reduced the pain at 15 minutes, which was repeated at 30 minutes (median change: 63, 95% CI: 57 to 65 vs 55.5, 95% CI: 50 to 59, respectively). Pain improvement in the dexketoprofen group was better than in the paracetamol group at 15 (median difference: 8, 95% CI: 0 to 16, p=0.048) and 30 (median difference: 6, 95% CI: 1 to 12, p=0.028) minutes, which was statistically significant but not clinically significant. Conclusion: Dexketotoprofen has a better visual analogue scale score that is not clinically relevant compared to paracetamol. © 2018, Galenos Publishing House. All rights reserved.
- Subjects :
- double blind procedure
paracetamol
medicine.medical_treatment
lcsh:Medicine
dysmenorrhea
law.invention
Menstruation
0302 clinical medicine
Randomized controlled trial
Interquartile range
law
arveles
nonsteroid antiinflammatory agent
030212 general & internal medicine
Prospective Studies
Saline
adult
Dexketoprofen,dysmenorrhea,intravenous,paracetamol,treatment
Anti-Inflammatory Agents, Non-Steroidal
pelvic pain
General Medicine
female
Anesthesia
Original Article
pain severity
medicine.symptom
menstruation
Intravenous
medicine.drug
prospective study
ketoprofen
Visual analogue scale
Pain
complication
intention to treat analysis
pain measurement
Article
03 medical and health sciences
Young Adult
Double-Blind Method
medicine
Dexketoprofen
Humans
controlled study
human
Acetaminophen
business.industry
Pelvic pain
lcsh:R
visual analog scale
030208 emergency & critical care medicine
Emergency department
major clinical study
Treatment
randomized controlled trial
treatment outcome
business
Subjects
Details
- ISSN :
- 21463123
- Database :
- OpenAIRE
- Journal :
- Volume: 35, Issue: 4 301-305, Balkan Medical Journal, Balkan Medical Journal, Vol 35, Iss 4, Pp 301-305 (2018)
- Accession number :
- edsair.doi.dedup.....bb045167feb966f6d3bae279e4ffd291