Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis

BACKGROUND: Classically histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016 WHO reclassified gliomas based on histology and molecular characteristics. OBJECTIVE: We sought to determine whether molecular classification of gliomas is associated with pre-operative seizure presentation and/or post-operative seizure control across multiple glioma subtypes. METHODS: All gliomas operated at our institution from 2007–2017 were identified based on ICD 9 and 10 billing codes and were retrospectively assessed for molecular classification of the IDH1 mutation, and 1p/19q codeletion. Logistic regression models were performed to assess associations of seizures at presentation as well as post-operative seizures with IDH status and the new WHO integrated classification. RESULTS: Our study included 376 patients: 82 IDH mutant and 294 IDH wildtype. Presence of IDH mutation was associated with seizures at presentation [OR=3.135 (1.818–5.404), p