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Perinatal HCV Transmission Rate in HIV/HCV Coinfected women with access to ART in Madrid, Spain
- Source :
- PLoS ONE, Vol 15, Iss 4, p e0230109 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Background Maternal HIV coinfection is a key factor for mother-to-child transmission (MTCT) of HCV. However, data about HCV MTCT in HIV/HCV-coinfected pregnant women on combined antiretroviral treatment (ART) are scarce. This study assessed the HCV MTCT rate in the Madrid Cohort of HIV-infected women. Methods Retrospective study within the Madrid Cohort of HIV-infected pregnant women (2000-2012). Epidemiological, clinical and treatment related variables were analysed for the mother and infant pairs. HCV MTCT rate was determined. Results Three hundred thirty-nine HIV/HCV-coinfected women and their exposed infants were recorded. A total of 227 (67%) paired mother-children had available data of HCV follow-up and were included for the analysis. Sixteen children (rate 7.0%, 95%CI 3.7-10.4%) were HCV infected by 18 months of age, none of them coinfected with HIV. HIV/HCV-coinfected pregnant women were mostly of Spanish origin with a background of previous injection drug use. HCV-genotype 1 was predominant. The characteristics of mothers that transmitted HCV were similar to those that did not transmit HCV with respect to sociodemographic and clinical features. A high rate (50%) of preterm deliveries was observed. Infants infected with HCV were similar at birth in weight, length and head circumference than those uninfected. Conclusion MTCT rates of HCV among HIV/HCV-coinfected women on ART within the Madrid cohort were lower than previously described. However, rates are still significant and strategies to eliminate any HCV transmission from mother to child are needed.
- Subjects :
- RNA viruses
Male
Maternal Health
Hcv transmission
HIV Infections
Hepacivirus
Pediatrics
Health Services Accessibility
Families
0302 clinical medicine
Immunodeficiency Viruses
Pregnancy
Antiretroviral Therapy, Highly Active
Epidemiology
Medicine
Public and Occupational Health
030212 general & internal medicine
Children
Pathology and laboratory medicine
Multidisciplinary
Obstetrics
Transmission (medicine)
Hepatitis C virus
Coinfection
Obstetrics and Gynecology
virus diseases
Medical microbiology
Viral Load
Vaccination and Immunization
Hepatitis C
Cohort
Viruses
030211 gastroenterology & hepatology
Female
Pathogens
Pediatric Infections
Infants
Research Article
Adult
medicine.medical_specialty
Mother to child transmission
Science
Immunology
Mothers
Antiretroviral Therapy
Microbiology
Injection drug use
03 medical and health sciences
Antiviral Therapy
Virology
Retroviruses
Humans
Medicine and health sciences
Biology and life sciences
Flaviviruses
business.industry
Lentivirus
Organisms
Viral pathogens
Infant, Newborn
HIV
Infant
Retrospective cohort study
medicine.disease
Hepatitis viruses
digestive system diseases
Microbial pathogens
Age Groups
Spain
People and Places
Women's Health
Population Groupings
Preventive Medicine
business
Viral Transmission and Infection
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....bafc162982eea651f42ceb5bd243577c