Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination

Authors :: Bronwyn MacInnis
Crystal M. North
Zahra Reynolds
Rebecca F Gilbert
James Regan
Chana A. Sacks
Katherine J. Siddle
Mark J. Siedner
Julie Boucau
Delaney D Ding
Anand S. Dighe
Jatin M. Vyas
James P. Flynn
Robert H. Goldstein
Andrew J. Kim
Amy K. Barczak
Lindsey R. Baden
Karl Laskowski
Brian C. Healy
Jonathan Z. Li
Dianne M. Finkelstein
Ann E. Woolley
Jacob E. Lemieux
Tammy Vyas
Manish Chandra Choudhary
Bennett M. Shaw
Source :: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Publication Year :: 2021
Publisher :: Oxford University Press (OUP), 2021.
Abstract: The impact of coronavirus disease 2019 vaccination on viral characteristics of breakthrough infections is unknown. In this prospective cohort study, incidence of severe acute respiratory syndrome coronavirus 2 infection decreased following vaccination. Although asymptomatic positive tests were observed following vaccination, the higher cycle thresholds, repeat negative tests, and inability to culture virus raise questions about their clinical significance.

Full Text Access

Tools