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Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia
- Source :
- Bai, H, Guo, X, Narisu, N, Lan, T, Wu, Q, Xing, Y, Zhang, Y, Bond, S R, Pei, Z, Zhang, Y, Zhang, D, Jirimutu, J, Zhang, D, Yang, X, Morigenbatu, M, Zhang, L, Ding, B, Guan, B, Cao, J, Lu, H, Liu, Y, Li, W, Dang, N, Jiang, M, Wang, S, Xu, H, Wang, D, Liu, C, Luo, X, Gao, Y, Li, X, Wu, Z, Yang, L, Meng, F, Ning, X, Hashenqimuge, H, Wu, K, Wang, B, Suyalatu, S, Liu, Y, Ye, C, Wu, H, Leppälä, K, Li, L, Fang, L, Chen, Y, Xu, W, Li, T, Liu, X, Xu, X, Gignoux, C R, Yang, H, Brody, L C, Wang, J, Kristiansen, K, Burenbatu, B, Zhou, H & Yin, Y 2018, ' Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia ', Nature Genetics, vol. 50, pp. 1696–1704 . https://doi.org/10.1038/s41588-018-0250-5
- Publication Year :
- 2018
-
Abstract
- The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation in the panel shows strong population stratification among these tribes, which correlates with the diverse demographic histories in the region. Incorporating our results with the 1000 Genomes Project panel identifies derived alleles shared between Finns and Mongolians/Siberians, suggesting that substantial gene flow between northern Eurasian populations has occurred in the past. Furthermore, we highlight that North, East, and Southeast Asian populations are more aligned with each other than these groups are with South Asian and Oceanian populations.
- Subjects :
- 0301 basic medicine
Gene Flow
Male
Population
Biology
Population stratification
Southeast asian
Gene flow
03 medical and health sciences
0302 clinical medicine
Asian People
Genetic variation
Genetics
Humans
East Asia
1000 Genomes Project
education
Phylogeny
education.field_of_study
Whole Genome Sequencing
Asia, Eastern
Genome, Human
Mongolia
Genetic architecture
Europe
030104 developmental biology
Genetics, Population
Evolutionary biology
Asia, Northern
Female
Americas
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Bai, H, Guo, X, Narisu, N, Lan, T, Wu, Q, Xing, Y, Zhang, Y, Bond, S R, Pei, Z, Zhang, Y, Zhang, D, Jirimutu, J, Zhang, D, Yang, X, Morigenbatu, M, Zhang, L, Ding, B, Guan, B, Cao, J, Lu, H, Liu, Y, Li, W, Dang, N, Jiang, M, Wang, S, Xu, H, Wang, D, Liu, C, Luo, X, Gao, Y, Li, X, Wu, Z, Yang, L, Meng, F, Ning, X, Hashenqimuge, H, Wu, K, Wang, B, Suyalatu, S, Liu, Y, Ye, C, Wu, H, Leppälä, K, Li, L, Fang, L, Chen, Y, Xu, W, Li, T, Liu, X, Xu, X, Gignoux, C R, Yang, H, Brody, L C, Wang, J, Kristiansen, K, Burenbatu, B, Zhou, H & Yin, Y 2018, ' Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia ', Nature Genetics, vol. 50, pp. 1696–1704 . https://doi.org/10.1038/s41588-018-0250-5
- Accession number :
- edsair.doi.dedup.....bad35f0187a2180915c5a4f17a3e7c48
- Full Text :
- https://doi.org/10.1038/s41588-018-0250-5