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Evaluation of clinical staging in chronic lymphocytic leukemia- population-based study
- Source :
- Leukemia & Lymphoma. 47:2505-2516
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- The Rai and Binet staging systems are currently being challenged by the development of new biological methods to characterize the prognosis and management of chronic lymphocytic leukemia (CLL). To evaluate these two systems in recently diagnosed CLL patients, we performed a retrospective population-based study including 344 patients in western Sweden diagnosed between 1995 and 2000. Binet stage A patients had longer median overall survival (OS) (100 months) than stage B (55 months; P < 0.001) and C patients (45 months; P < 0.0005). Median OS for stage B and C could not be separated (P = 0.94). When transferring Rai stages into three groups, a similar pattern was found. Overall response differed only between Binet A and C patients and there was no difference regarding time to next treatment between any of the Binet stages. Finally, in both systems, low stage patients had inferior survival compared to age- and sex-matched controls. Our data emphasize the need for a new risk stratification system for CLL pat...
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Time Factors
Chronic lymphocytic leukemia
Population
Time to next treatment
Disease-Free Survival
Overall response rate
hemic and lymphatic diseases
Internal medicine
medicine
Overall survival
Humans
Stage (cooking)
education
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
education.field_of_study
business.industry
Hematology
Middle Aged
Prognosis
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Surgery
Population based study
Treatment Outcome
Case-Control Studies
Risk stratification
Female
business
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....bacbbf5e502012a56ee87b92dd71b9e2