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Long-range silencing and position effects at telomeres and centromeres: parallels and differences
- Source :
- Cellular and Molecular Life Sciences, Vol. 60, No 11 (2003) pp. 2303-2318
- Publication Year :
- 2018
-
Abstract
- Most of the human genome is compacted into heterochromatin, a form that encompasses multiple forms of inactive chromatin structure. Transcriptional silencing mechanisms in budding and fission yeasts have provided genetically tractable models for understanding heritably repressed chromatin. These silent domains are typically found in regions of repetitive DNA, that is, either adjacent to centromeres or telomeres or within the tandemly repeated ribosomal DNA array. Here we address the mechanisms of centromeric, telomeric and locus-specific gene silencing, comparing simple and complex animals with yeast. Some aspects are universally shared, such as histone-tail modifications, while others are unique to either centromeres or telomeres. These may reflect roles for heterochromatin in other chromosomal functions, like kinetochore attachment and DNA ends protection.
- Subjects :
- Heterochromatin
Centromere
Biology
Methylation
Histone Deacetylases
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Sirtuin 2
ddc:570
Schizosaccharomyces
Animals
Humans
Sirtuins
Epigenetics
Gene Silencing
Repeated sequence
Molecular Biology
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Pharmacology
Genetics
Cell Biology
Telomere
Chromatin
chemistry
Saccharomycetales
Molecular Medicine
Heterochromatin protein 1
Human genome
RNA Interference
DNA
Subjects
Details
- Language :
- English
- ISSN :
- 1420682X
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences, Vol. 60, No 11 (2003) pp. 2303-2318
- Accession number :
- edsair.doi.dedup.....bac5adff7af12e6693a2bed9b08588ca