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Idiotypic–Anti-idiotypic B Cell Interactions Generated against a Protective Antigen of a Morbillivirus in Mice
- Source :
- Cellular Immunology. 209:10-18
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- The idiotypic network theory (N. K. Jerne, Ann. Immunol. 125, 373–389, 1974) predicts that any antibody that can be made by an individual would have its preexisting specific complementary B cells in its germline repertoire. We transplanted syngeneic BALB/c mice with live hybridoma cells and demonstrated the simultaneous presence of interacting idiotypic and anti-idiotypic B cells in an individual animal by immuno-cytoadherence assays. Furthermore, we demonstrate that interacting B cells displaying idiotypic and anti-idiotypic antibodies are subjected to lysis by complement. It is therefore tempting to speculate that this complement-sensitive interaction between idiotypic and complementary anti-idiotypic B cells in vivo may provide a mechanism for the regulation of B cell populations.
- Subjects :
- Male
Rinderpest
Lysis
Immunology
Naive B cell
Hemagglutinins, Viral
Biochemistry
Germline
Mice
Viral Proteins
Immunoglobulin Idiotypes
Morbillivirus
In vivo
Cell Adhesion
medicine
Animals
Antigens, Viral
B cell
Glycoproteins
Microbiology & Cell Biology
B-Lymphocytes
Mice, Inbred BALB C
Hybridomas
biology
Models, Immunological
Complement System Proteins
biology.organism_classification
Molecular biology
Antibodies, Anti-Idiotypic
medicine.anatomical_structure
Protective antigen
biology.protein
Female
Antibody
Spleen
Subjects
Details
- ISSN :
- 00088749
- Volume :
- 209
- Database :
- OpenAIRE
- Journal :
- Cellular Immunology
- Accession number :
- edsair.doi.dedup.....bac23b899fbca0609ed54a28247fd8ff