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Y-box binding protein-1 expression in diffuse large B-cell lymphoma: an impact on prognosis in the rituximab era
- Source :
- Leukemia & Lymphoma. 51:2054-2062
- Publication Year :
- 2010
- Publisher :
- Informa UK Limited, 2010.
-
Abstract
- The expression of YB-1 has been reported to predict poor clinical outcome in many human malignancies, including hematopoietic malignancies. In this study, we investigated the correlations between YB-1 expression and the clinicopathological features of patients with diffuse large B-cell lymphoma (DLBCL) in a single institution. The expression of YB-1 was analyzed in 168 cases by immunohistochemistry. Fifteen out of 168 cases (8.9%) showed cytoplasmic expression of YB-1. The expression of YB-1 was significantly associated with 5-year overall survival (OS) (p = 0.023). Rituximab plus CHOP therapy (n = 94) improved the 5-year survival rate in both YB-1-positive and -negative patients. In conclusion, the data presented in this report provide evidence that the cytoplasmic expression of YB-1 is a poor prognosis factor in DLBCL treated with CHOP therapy, whereas rituximab improves the survival of both YB-1-positive and -negative patients with DLBCL.
- Subjects :
- Adult
Male
Oncology
Cancer Research
Pathology
medicine.medical_specialty
Antineoplastic Agents
CHOP
Biomarkers, Pharmacological
Antibodies, Monoclonal, Murine-Derived
immune system diseases
hemic and lymphatic diseases
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Humans
Medicine
Cyclophosphamide
Survival rate
Aged
Aged, 80 and over
business.industry
Hematology
Middle Aged
Y box binding protein 1
Prognosis
medicine.disease
Survival Analysis
Lymphoma
Haematopoiesis
Doxorubicin
Vincristine
Prednisone
Immunohistochemistry
Female
Rituximab
Lymphoma, Large B-Cell, Diffuse
Y-Box-Binding Protein 1
business
Diffuse large B-cell lymphoma
medicine.drug
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....bac203a8d3b3898fee8afd5b96ef4eee
- Full Text :
- https://doi.org/10.3109/10428194.2010.522285