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The risk of not receiving adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma
- Source :
- HPB: The official journal of the International Hepato Pancreato Biliary Association, 22(2), 233-240. John Wiley and Sons Inc., Hpb, 22, 2, pp. 233-240, International Hepato-Pancreato Biliary Association., 22(2), 233. John Wiley and Sons Inc., HPB, 22(2), 233-240. ELSEVIER SCI LTD, HPB, 22(2), 233-240. John Wiley and Sons Inc., HPB, 22(2), 233-240. John Wiley & Sons Inc., Hpb, 22(2), 233-240. ELSEVIER SCI LTD, Mackay, T M, Smits, F J, Roos, D, Bonsing, B A, Bosscha, K, Busch, O R, Creemers, G-J, van Dam, R M, van Eijck, C H J, Gerhards, M F, de Groot, J W B, Groot Koerkamp, B, Haj Mohammad, N, van der Harst, E, de Hingh, I H J T, Homs, M Y V, Kazemier, G, Liem, M S L, de Meijer, V E, Molenaar, I Q, Nieuwenhuijs, V B, van Santvoort, H C, van der Schelling, G P, Stommel, M W J, ten Tije, A J, de Vos-Geelen, J, Wit, F, Wilmink, J W, van Laarhoven, H W M, Besselink, M G & Dutch Pancreatic Cancer Group 2020, ' The risk of not receiving adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: a nationwide analysis ', HPB, vol. 22, no. 2, pp. 233-240 . https://doi.org/10.1016/j.hpb.2019.06.019, Hpb, 22, 233-240
- Publication Year :
- 2020
- Publisher :
- ELSEVIER SCI LTD, 2020.
-
Abstract
- Contains fulltext : 226028.pdf (Publisher’s version ) (Closed access) BACKGROUND: The relation between type of postoperative complication and not receiving chemotherapy after resection of pancreatic ductal adenocarcinoma (PDAC) is unclear. The aim was to investigate which patient factors and postoperative complications were associated with not receiving adjuvant chemotherapy. METHODS: Patients who underwent resection (2014-2017) for PDAC were identified from the nationwide mandatory Dutch Pancreatic Cancer Audit. The association between patient-, tumor-, center-, treatment characteristics, and the risk of not receiving adjuvant chemotherapy was analyzed with multivariable logistic regression. RESULTS: Overall, of 1306 patients, 24% (n = 312) developed postoperative Clavien Dindo ≥3 complications. In-hospital mortality was 3.5% (n = 46). Some 433 patients (33%) did not receive adjuvant chemotherapy. Independent predictors (all p
- Subjects :
- Male
SURGERY
medicine.medical_treatment
INTERNATIONAL STUDY-GROUP
030230 surgery
SURGICAL COMPLICATIONS
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
Risk Factors
Odds Ratio
Hospital Mortality
POSTOPERATIVE COMPLICATIONS
Netherlands
Gastroenterology
Age Factors
Middle Aged
Pancreaticoduodenectomy
OPEN-LABEL
CANCER
Pancreatic fistula
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
PANCREATICODUODENECTOMY
Female
medicine.drug
Carcinoma, Pancreatic Ductal
medicine.medical_specialty
Hospitals, Low-Volume
03 medical and health sciences
Pancreatectomy
Pancreatic cancer
medicine
Journal Article
Humans
Aged
Retrospective Studies
Chemotherapy
Performance status
Hepatology
business.industry
MORTALITY
Postoperative complication
Odds ratio
medicine.disease
Gemcitabine
Surgery
Pancreatic Neoplasms
Logistic Models
DEFINITION
GEMCITABINE
Neoplasm Grading
business
Subjects
Details
- Language :
- English
- ISSN :
- 1365182X
- Volume :
- 22
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Hpb
- Accession number :
- edsair.doi.dedup.....bab622c8bf9a5f70c9a901ded91a0d35
- Full Text :
- https://doi.org/10.1016/j.hpb.2019.06.019