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Histologic and Outcome Study Supports Reclassifying Appendiceal Goblet Cell Carcinoids as Goblet Cell Adenocarcinomas, and Grading and Staging Similarly to Colonic Adenocarcinomas
- Source :
- American Journal of Surgical Pathology. 42:898-910
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- Goblet cell carcinoid tumors are amphicrine tumors whose biological behavior ranges from indolent to highly aggressive, depending on tumor grade. Current grading systems for these tumors are based on identifying an adenocarcinoma arising in the setting of a goblet cell carcinoid tumor, which distinguishes this tumor from other gastrointestinal tract adenocarcinomas. Because goblet cell tumors are predominantly tumors of mucin secreting cells, we propose that they be classified as goblet cell adenocarcinomas, and graded using a methodology that has parallels in colorectal adenocarcinoma grading. We graded a large series of goblet cell adenocarcinomas by assessing the proportion of the tumor that demonstrates tubular or clustered growth. Histologic grade correlated with overall survival independent of stage, with median overall survival of 204, 86, and 29 months for low-grade, intermediate-grade, and high-grade goblet cell adenocarcinomas, respectively. Tumor stage also correlated with overall survival. We also graded the tumors according to previously proposed grading systems, and found that these systems are valid, in that they segregate patients according to prognosis.
- Subjects :
- Adult
Male
0301 basic medicine
Pathology
medicine.medical_specialty
Biopsy
Carcinoid Tumor
Adenocarcinoma
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Terminology as Topic
Humans
Medicine
Stage (cooking)
Grading (tumors)
Goblet cell carcinoid
Aged
Neoplasm Staging
Aged, 80 and over
Neoplasm Grading
Goblet cell
medicine.diagnostic_test
business.industry
Mucin
Middle Aged
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Appendiceal Neoplasms
030220 oncology & carcinogenesis
Colonic Neoplasms
Female
Surgery
Goblet Cells
Anatomy
business
Subjects
Details
- ISSN :
- 01475185
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- American Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....bab587328e1782431f59376ce3715651
- Full Text :
- https://doi.org/10.1097/pas.0000000000001056