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Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part II. Some contributions of Manfred Göthert
- Source :
- Pharmacological reports : PR. 72(2)
- Publication Year :
- 2019
-
Abstract
- About 40% of the papers within the scientific oeuvre of Manfred Göthert (1939–2019) were dedicated to serotonin (5-hydroxytryptamine, 5-HT). He was not only the witness of the gradual definition of the fourteen 5-HT receptor subtypes but also was involved directly by identifying 5-HT1B, 5-HT1D and 5-HT3 receptors. Moreover, he identified presynaptic 5-HT receptors on central and/or peripheral serotoninergic, noradrenergic and/or cholinergic neurones. Two inhibitory (5-HT1B, 5-HT1D) and two facilitatory (5-HT3, 5-HT4) receptors were found, the 5-HT1B receptor representing a possible target for antidepressant drugs. Ten years earlier than electrophysiologists, he identified ligand-gated receptors like the 5-HT3 and the nicotinic acetylcholine (nACh) receptor as targets of halothane. Simultaneously with, but independent of, other authors he found that ethanol allosterically inhibits N-methyl-d-aspartate (NMDA) receptors, which are affected at an even lower concentration than 5-HT3 and nACh receptors. The latter two receptors were shown to be subject to allosteric inhibition also by cannabinoids via a mechanism unrelated to cannabinoid CB1 or CB2 receptors; cannabinoid inhibition of 5-HT3 receptors may represent a new target for the treatment of neuropathic pain.
- Subjects :
- 0301 basic medicine
Serotonin
Cannabinoid receptor
medicine.medical_treatment
History, 21st Century
03 medical and health sciences
0302 clinical medicine
Drug Discovery
medicine
Cannabinoid receptor type 2
Animals
Humans
Receptor
5-HT receptor
Pharmacology
Chemistry
General Medicine
History, 20th Century
Antidepressive Agents
030104 developmental biology
Nicotinic agonist
Receptors, Serotonin
Cannabinoid
Neuroscience
030217 neurology & neurosurgery
Acetylcholine
Selective Serotonin Reuptake Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 22995684
- Volume :
- 72
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Pharmacological reports : PR
- Accession number :
- edsair.doi.dedup.....ba91e0f608b08142c8c65e57467f542a