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Genome-Wide Association Studies of Drug-Resistance Determinants
- Source :
- Trends in parasitology. 33(3)
- Publication Year :
- 2016
-
Abstract
- Population genetic strategies that leverage association, selection, and linkage have identified drug-resistant loci. However, challenges and limitations persist in identifying drug-resistance loci in malaria. In this review we discuss the genetic basis of drug resistance and the use of genome-wide association studies, complemented by selection and linkage studies, to identify and understand mechanisms of drug resistance and response. We also discuss the implications of nongenetic mechanisms of drug resistance recently reported in the literature, and present models of the interplay between nongenetic and genetic processes that contribute to the emergence of drug resistance. Throughout, we examine artemisinin resistance as an example to emphasize challenges in identifying phenotypes suitable for population genetic studies as well as complications due to multiple-factor drug resistance.
- Subjects :
- 0301 basic medicine
Population
Plasmodium falciparum
Drug Resistance
Genome-wide association study
Drug resistance
Biology
03 medical and health sciences
Antimalarials
Genetic linkage
medicine
Humans
education
Selection (genetic algorithm)
Genetic association
Genetics
Genetic Processes
education.field_of_study
medicine.disease
Artemisinins
Malaria
030104 developmental biology
Infectious Diseases
Genetics, Population
Parasitology
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14715007
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Trends in parasitology
- Accession number :
- edsair.doi.dedup.....ba843310b9a251977832f0bfeefb7e95