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Evaluation of the Dose-Dependent Effects of Fermented Mixed Grain Enzyme Food on Adiposity and Its Metabolic Disorders in High-Fat Diet-Induced Obese Mice
- Source :
- Journal of medicinal food. 24(8)
- Publication Year :
- 2021
-
Abstract
- Ancient traditions showed that fermented enzyme foods have beneficial health effects on the body. However, only a few studies have reported on its impact on weight loss and metabolic syndrome. Therefore, it is necessary to verify whether diet supplementation with fermented enzyme foods can have a beneficial functional impact on the body. We examined the antiobesity properties of fermented mixed grain (FMG) with digestive enzymes (FMG) in diet-induced obese mice. Sixty C57BL/6J mice were randomly assigned to six dietary groups: (1) normal diet (ND), (2) high-fat diet (HFD), (3) Bacilus Coagulans, (4) steamed grain, (5) low-dose FMG (L-FMG), and (6) high-dose FMG (H-FMG) supplement for 12 weeks. The results showed that H-FMG supplement dramatically decreased body weight and fat mass with simultaneous decreases in plasma lipid contents. Furthermore, H-FMG significantly lowered fasting blood glucose concentrations and improved glucose tolerance compared with the HFD group. Also, the concentrations of inflammatory cytokines secreted from adipocytes in H-FMG-supplemented mice decreased dramatically. Taken together, our findings indicated that H-FMG can ameliorate HFD-induced obesity and its associated complications and could be used as a potential preventive intervention for obesity.
- Subjects :
- medicine.medical_specialty
Normal diet
Medicine (miscellaneous)
Mice, Obese
Diet, High-Fat
Proinflammatory cytokine
Mice
Metabolic Diseases
Weight loss
Internal medicine
medicine
Animals
Obesity
Adiposity
chemistry.chemical_classification
Nutrition and Dietetics
biology
business.industry
Body Weight
food and beverages
medicine.disease
Mice, Inbred C57BL
Endocrinology
Enzyme
Nutrigenomics
chemistry
Digestive enzyme
biology.protein
Metabolic syndrome
medicine.symptom
business
Subjects
Details
- ISSN :
- 15577600
- Volume :
- 24
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of medicinal food
- Accession number :
- edsair.doi.dedup.....ba7f97e149ae81270b2fe2bb17820f2b