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Clinical and economic impact of treated CMV infection in adult CMV‐seropositive patients after allogeneic hematopoietic cell transplantation
- Source :
- Journal of Medical Virology, Journal of Medical Virology, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩, Journal of Medical Virology, Wiley-Blackwell, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- OBJECTIVE Recipients of allogeneic hematopoietic stem cell transplantation (allo-HCT) with positive cytomegalovirus (CMV) serology are at increased risk of morbidity and mortality. The primary objective of this study was to assess the association between treated CMV infection and overall mortality within 1 year after allo-HCT in adult CMV-seropositive Recipients (R+). Secondary objectives included overall 5-year mortality after allo-HCT, risk factors for treated CMV infection, associations between treated CMV infection and allo-HCT complications and medical costs. METHODS A multicenter retrospective cohort study was conducted in adult CMV-seropositive recipients (R+) who underwent to allo-HCT between 1st January 2010 and 31st December 2014. RESULTS Five hundred seventy two CMV-seropositive patients (mean age, 50.2 years) undergoing allo-HCT between 2010 and 2014 were included; 55.9% of donors were CMV seropositive. CMV infection treated with antiviral therapy was reported in 227 patients (39.7%) after transplantation. One-year overall mortality was significantly increased in patients with treated CMV infections (hazard ratio, 1.86; 95% CI, 1.16-3.00; P = .011). Mean medical costs during the first post-HCT year were higher in patients with CMV infection (€46 853 vs €31 318; P
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Congenital cytomegalovirus infection
Hematopoietic stem cell transplantation
Serology
03 medical and health sciences
0302 clinical medicine
Virology
Internal medicine
medicine
In patient
030212 general & internal medicine
ComputingMilieux_MISCELLANEOUS
Hematopoietic cell
business.industry
Hazard ratio
virus diseases
Retrospective cohort study
medicine.disease
3. Good health
Transplantation
Infectious Diseases
[SDV.IMM]Life Sciences [q-bio]/Immunology
030211 gastroenterology & hepatology
business
Subjects
Details
- Language :
- English
- ISSN :
- 01466615 and 10969071
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Virology, Journal of Medical Virology, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩, Journal of Medical Virology, Wiley-Blackwell, 2020, 92 (12), pp.3665-3673. ⟨10.1002/jmv.25895⟩
- Accession number :
- edsair.doi.dedup.....ba72438b7253989063065316198bd375