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EXPRESSION OF SPECIFIC PROTEIN KINASE C (PKC) ISOFORMS AND LIGAND-SPECIFIC ACTIVATION OF PKCα IN LATE GESTATION FETAL LUNG
- Source :
- Experimental Lung Research. 33:185-196
- Publication Year :
- 2007
- Publisher :
- Informa UK Limited, 2007.
-
Abstract
- Epidermal growth factor receptor signaling plays an important role in lung maturation. The authors hypothesized that specific protein kinase C (PKC) isoforms are expressed and activated by epidermal growth factor (EGF) and transforming growth factor alpha (TGFalpha) (EGF receptor [EGFR] ligands) in fetal lung fibroblasts. The authors found 4 PKC isoforms expressed in gestational day 19 (d19) fetal rat lung fibroblasts, and focused on PKCalpha because of its developmental expression pattern. PKCalpha immunolocalization in d17, d19, and d21 fetal lung fibroblasts was similar to EGFR. PKCalpha expression decreased with lung maturation. EGF, but not TGFalpha, stimulated PKCalpha activation and membrane translocation. Further studies of PKCalpha functions in fetal lung development are clearly needed.
- Subjects :
- Pulmonary and Respiratory Medicine
Gene isoform
Protein Kinase C-alpha
Clinical Biochemistry
Gestational Age
Protein Kinase C-epsilon
Rats, Sprague-Dawley
Pregnancy
Epidermal growth factor
Animals
Epidermal growth factor receptor
Receptor
Lung
Molecular Biology
Cells, Cultured
Protein Kinase C
Protein kinase C
Epidermal Growth Factor
biology
Chemistry
Kinase
Fibroblasts
Transforming Growth Factor alpha
respiratory system
Rats
Cell biology
Enzyme Activation
ErbB Receptors
Protein Transport
Cancer research
biology.protein
Female
Signal transduction
Signal Transduction
Transforming growth factor
Subjects
Details
- ISSN :
- 15210499 and 01902148
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Experimental Lung Research
- Accession number :
- edsair.doi.dedup.....ba5e07e9774def959d2f535e4c46896c