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T3+and T4 Rectal Cancer Patients Seem to Benefit From the Addition of Oxaliplatin to the Neoadjuvant Chemoradiation Regimen
- Source :
- Annals of Surgical Oncology, 19(2), 392-401
- Publication Year :
- 2012
-
Abstract
- To achieve T-downstaging and better resectability in locally advanced rectal cancer, neoadjuvant radiochemotherapy (RCT) has become the current standard of treatment. A variety of schemes have been used. This study investigates which scheme had the best effect on these parameters. Our institution is a referral center for locally advanced rectal cancer. Different neoadjuvant radiochemotherapy regimens were administered: long course radiotherapy (RTH), 5-FU and leucovorin (5FUBolus), a combination of capecitabine and oxaliplatin (CORE), and capecitabine only (CAP). Selection of patients for 1 of the regimens was based on hospital policy rather than patient or tumor characteristics. The data of 504 consecutive patients (n = 181 T3+, n = 323 T4) without metastatic disease (cM0) who underwent surgery for advanced rectal carcinoma between 1994 and 2010 were reviewed. The RTH, 5FUBolus, CORE, and CAP scheme were administered to 106, 137, 155, and 106 patients, respectively. Odds ratios for downstaging were less effective for RTH, 5FUBolus, and CAP (0.31, 0.44, and 0.31; P
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Organoplatinum Compounds
Colorectal cancer
medicine.medical_treatment
Leucovorin
Adenocarcinoma
Deoxycytidine
Capecitabine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Preoperative Care
medicine
Humans
Prospective Studies
Survival rate
Neoadjuvant therapy
Aged
Neoplasm Staging
Aged, 80 and over
business.industry
Rectal Neoplasms
Chemoradiotherapy
Middle Aged
medicine.disease
Neoadjuvant Therapy
Oxaliplatin
Radiation therapy
Survival Rate
Regimen
Treatment Outcome
Surgery
Female
Fluorouracil
business
medicine.drug
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology, 19(2), 392-401
- Accession number :
- edsair.doi.dedup.....ba4a82bd561c2f33d398e8ac8e514d65