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Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study
- Source :
- Human Genetics, Human Genetics, 2017, 136 (7), pp.897-902. ⟨10.1007/s00439-017-1811-x⟩, Human Genetics, Springer Verlag, 2017, 136 (7), pp.897-902. 〈10.1007/s00439-017-1811-x〉, Human Genetics, 136(7), 897-902, Human Genetics, Springer Verlag, 2017, 136 (7), pp.897-902. ⟨10.1007/s00439-017-1811-x⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; Observational studies have shown an association between obesity and venous thromboembolism (VTE) but it is not known if observed associations are causal, due to reverse causation or confounding bias. We conducted a Mendelian Randomization study of body mass index (BMI) and VTE. We identified 95 single nucleotide polymorphisms (SNPs) that have been previously associated with BMI and assessed the association between genetically predicted high BMI and VTE leveraging data from a previously conducted GWAS within the INVENT consortium comprising a total of 7507 VTE cases and 52,632 controls of European ancestry. Five BMI SNPs were associated with VTE at P < 0.05, with the strongest association seen for the FTO SNP rs1558902 (OR 1.07, 95% CI 1.02–1.12, P = 0.005). In addition, we observed a significant association between genetically predicted BMI and VTE (OR = 1.59, 95% CI 1.30–1.93 per standard deviation increase in BMI, P = 5.8 × 10−6). Our study provides evidence for a causal relationship between high BMI and risk of VTE. Reducing obesity levels will likely result in lower incidence in VTE.
- Subjects :
- Male
Genome-wide association study
030204 cardiovascular system & hematology
Body Mass Index
0302 clinical medicine
030212 general & internal medicine
Genetics (clinical)
2. Zero hunger
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Incidence
Confounding
[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie
[ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
[ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
3. Good health
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Female
Adult
medicine.medical_specialty
venous thromboembolism
SNP
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Article
White People
03 medical and health sciences
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
Mendelian randomization
Genetics
medicine
Humans
cardiovascular diseases
Obesity
Proportional Hazards Models
association
nutritional and metabolic diseases
Mendelian Randomization Analysis
medicine.disease
equipment and supplies
Logistic Models
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Case-Control Studies
Observational study
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Body mass index
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 03406717 and 14321203
- Database :
- OpenAIRE
- Journal :
- Human Genetics, Human Genetics, 2017, 136 (7), pp.897-902. ⟨10.1007/s00439-017-1811-x⟩, Human Genetics, Springer Verlag, 2017, 136 (7), pp.897-902. 〈10.1007/s00439-017-1811-x〉, Human Genetics, 136(7), 897-902, Human Genetics, Springer Verlag, 2017, 136 (7), pp.897-902. ⟨10.1007/s00439-017-1811-x⟩
- Accession number :
- edsair.doi.dedup.....ba384b75d8020190feccfef0816e130e