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Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
- Source :
- Bioorganic & Medicinal Chemistry Letters. 8:333-338
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.
- Subjects :
- inorganic chemicals
Proteasome Endopeptidase Complex
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Multienzyme Complexes
Drug Discovery
Peptide synthesis
Protease Inhibitors
Molecular Biology
chemistry.chemical_classification
Dipeptide
Molecular Structure
biology
Organic Chemistry
Boronic Acids
In vitro
Cysteine Endopeptidases
Enzyme
chemistry
Proteasome
Enzyme inhibitor
biology.protein
Molecular Medicine
Boronic acid
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....ba35bcdbd26e8db5d1f183ac78cb8945
- Full Text :
- https://doi.org/10.1016/s0960-894x(98)00029-8