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Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
- Source :
- Frontiers in neuroendocrinology, San Diego : Elsevier B.V., 2022, vol. 66, art. no. 100993, p. 1-27
- Publication Year :
- 2021
-
Abstract
- Physical exercise may improve cognitive function by modulating molecular and cellular mechanisms within the brain. We propose that the facilitation of long-term synaptic potentiation (LTP)-related pathways, by products induced by physical exercise (i.e., exerkines), is a crucial aspect of the exercise-effect on the brain. This review summarizes synaptic pathways that are activated by exerkines and may potentiate LTP. For a total of 16 exerkines, we indicated how blood and brain exerkine levels are altered depending on the type of physical exercise (i.e., cardiovascular or resistance exercise) and how they respond to a single bout (i.e., acute exercise) or multiple bouts of physical exercise (i.e., chronic exercise). This information may be used for designing individualized physical exercise programs. Finally, this review may serve to direct future research towards fundamental gaps in our current knowledge regarding the biophysical interactions between muscle activity and the brain at both cellular and system levels. ispartof: Frontiers In Neuroendocrinology vol:66 ispartof: location:United States status: Published online
- Subjects :
- Inflammation
Neuronal Plasticity
VASOACTIVE INTESTINAL POLYPEPTIDE
Endocrine and Autonomic Systems
SKELETAL-MUSCLE CELLS
Intracellular signaling peptides and proteins
exercise
myokine
long-term potentiation
synaptic plasticity
inflammation
intracellular signaling peptides and proteins
cytokines
neurotrophic factor
brain
biomarkers
INDUCED WEIGHT-LOSS
Long-Term Potentiation
Brain
Neurotrophic factor
Hippocampus
Synaptic plasticity
Cognition
Myokine
GROWTH-FACTOR-I
Long-term potentiation
PROTEIN-KINASE-II
Cytokines
PLASMA GHRELIN LEVELS
RESISTANCE EXERCISE
LOW-INTENSITY EXERCISE
Exercise
AGE-RELATED ALTERATIONS
Biomarkers
Subjects
Details
- ISSN :
- 10956808 and 00913022
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Frontiers in neuroendocrinology
- Accession number :
- edsair.doi.dedup.....ba2ed59abc24f54dafece874545c9848