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Induction of neuronal damage in guinea pig brain by intratracheal infusion of 2-chloroethyl ethyl sulfide, a mustard gas analog
- Source :
- Journal of Biochemical and Molecular Toxicology. 26:23-30
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Intratracheal infusion of 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog and a chemical warfare agent is known to cause massive damage to lung. The purpose of this study was to determine whether intratracheal CEES infusion causes neuronal damage. Histological, immunohistochemical, and Western blot studies indicated that CEES treatment caused dose-dependent increases in blood cell aggregation, microglial cell number, microglial activation, and brain inflammation. In addition, an increased expression of α-synuclein and a decreased expression of the dopamine transporter were observed. The results indicate that intratracheal CEES infusion is associated with changes in brain morphology mediated by an increase in α-synuclein expression, leading to neurotoxicity in a guinea pig model. These changes may be mediated by oxidative stress. Furthermore, the present study indicates for the first time that intratracheal infusion of a single dose of CEES can cause neuroinflammation, which may lead to neurological disorders in later part of life. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:23–30 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20409
- Subjects :
- Male
Erythrocytes
Health, Toxicology and Mutagenesis
Guinea Pigs
Inflammation
Pharmacology
Toxicology
medicine.disease_cause
Biochemistry
Permeability
Guinea pig
Blood cell
Western blot
Mustard Gas
medicine
Animals
Tissue Distribution
Chemical Warfare Agents
Lung
Molecular Biology
Neuroinflammation
Dopamine transporter
Dopamine Plasma Membrane Transport Proteins
biology
medicine.diagnostic_test
Chemistry
Neurotoxicity
Brain
General Medicine
medicine.disease
Trachea
Oxidative Stress
medicine.anatomical_structure
Gene Expression Regulation
Brain Injuries
Anesthesia
alpha-Synuclein
biology.protein
Molecular Medicine
medicine.symptom
hormones, hormone substitutes, and hormone antagonists
Oxidative stress
Subjects
Details
- ISSN :
- 10956670
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Biochemical and Molecular Toxicology
- Accession number :
- edsair.doi.dedup.....ba2597864de2e07f03605b8c19c5311b