Back to Search
Start Over
A genetic mouse model of helplessness sensitive to imipramine
- Source :
- European Journal of Pharmacology, European Journal of Pharmacology, 1996, 316 (2-3), pp.R1-2. ⟨10.1016/s0014-2999(96)00800-x⟩
- Publication Year :
- 1996
-
Abstract
- Lines of mice were selectively bred to diverge in their spontaneous helplessness in the tail suspension test. By the second generation of selection, only mice of the helpless line were sensitive to the antidepressant imipramine. Genetic factors substantially contribute to the susceptibility to helplessness in this mouse model. These selectively bred lines may represent potentially useful animal models to investigate behavioural, neurochemical and neuroendocrine correlates of antidepressant action.
- Subjects :
- Male
Imipramine
Learned helplessness
Mice, Inbred Strains
Selective breeding
03 medical and health sciences
Mice
0302 clinical medicine
Animal model
Neurochemical
medicine
Animals
030304 developmental biology
Pharmacology
0303 health sciences
Depressive Disorder
Tail suspension test
Disease Models, Animal
Antidepressant
Female
Psychology
Neuroscience
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Clinical psychology
medicine.drug
Subjects
Details
- ISSN :
- 00142999 and 18790712
- Volume :
- 316
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....ba245e0ea56d25b8500d8aa0d3c44abf
- Full Text :
- https://doi.org/10.1016/s0014-2999(96)00800-x⟩