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The effect of hydrocortisone on reducing rates of restenosis and target lesion revascularization after coronary stenting less than 3 mm in stent diameter
- Source :
- Internal medicine (Tokyo, Japan). 42(11)
- Publication Year :
- 2003
-
Abstract
- Objective Stenting of small coronary arteries has always been limited by high rates of restenosis, and restenosis has mainly been attributed to inflammatory reactions resulting in cell proliferation and intimal hyperplasia. Based on our experience for several years, we retrospectively investigated the effect of hydrocortisone on reducing in-stent restenosis. Patients and Methods Study population consisted of consecutive 166 patients, 221 lesions, who electively underwent stent implantations stent diameter less than 3 mm into coronary arteries between February 1999 and October 2002. We intravenously administered hydrocortisone before the procedure to 40 patients for preventing allergic reactions due to contrast material, and the effect of hydrocortisone on reducing restenosis was retrospectively compared with 126 patients who did not receive this treatment. Results There was no significant difference in the prevalence of diabetes mellitus, hyperlipidemia, or hypertension between the two groups. There was no significant difference in the type of lesion, length of stent, balloon/artery ratio, or initial success rate between the two groups, but stent diameter was significantly smaller in the hydrocortisone group compared with the control group. On six-month angiographic follow-up, the restenosis rate was significantly lower in the hydrocortisone group compared with the control group (16.2% vs 34.0%, respectively), and the target lesion revascularization rate was also significantly lower in the hydrocortisone group compared with the control group (13.2% vs 27.5%, respectively). Conclusion These results suggest that intravenous administration of hydrocortisone reduces in-stent restenosis of small coronary arteries. Prospectively controlled trials will be necessary to confirm this preventive effect of hydrocortisone.(Internal Medicine 42: 1084-1089, 2003)
- Subjects :
- Male
medicine.medical_specialty
Intimal hyperplasia
Hydrocortisone
medicine.drug_class
medicine.medical_treatment
Urology
Anti-Inflammatory Agents
Lesion
Coronary Restenosis
Restenosis
Angioplasty
Internal Medicine
medicine
Humans
Angioplasty, Balloon, Coronary
Aged
Retrospective Studies
business.industry
Stent
General Medicine
Middle Aged
medicine.disease
Surgery
Coronary arteries
Radiography
medicine.anatomical_structure
Injections, Intravenous
Corticosteroid
Regression Analysis
Female
Stents
medicine.symptom
business
Artery
Subjects
Details
- ISSN :
- 09182918
- Volume :
- 42
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Internal medicine (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....ba2352b647d6d776cdfed1a39a010b66