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Multiaxial Lenticular Stress-Strain Relationship of Native Myocardium is Preserved by Infarct-Induced Natural Heart Regeneration in Neonatal Mice
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). Cardiac biomechanics intricately affect long-term heart function, but whether regenerated cardiac muscle is biomechanically similar to native myocardium remains unknown. We hypothesized that neonatal heart regeneration preserves native left ventricular (LV) biomechanical properties after MI. C57BL/6J mice underwent sham surgery or left anterior descending coronary artery ligation at age P1 or P7. Echocardiography performed 4 weeks post-MI showed that P1 MI and sham mice (n = 22, each) had similar LV wall thickness, diameter, and ejection fraction (59.6% vs 60.7%, p = 0.6514). Compared to P7 shams (n = 20), P7 MI mice (n = 20) had significant LV wall thinning, chamber enlargement, and depressed ejection fraction (32.6% vs 61.8%, p ex vivo, and the multiaxial lenticular stress-strain relationship was tracked. While LV tissue modulus for P1 MI and sham mice were similar (341.9 kPa vs 363.4 kPa, p = 0.6140), the modulus for P7 MI mice was significantly greater than that for P7 shams (691.6 kPa vs 429.2 kPa, p = 0.0194). We conclude that, in neonatal mice, regenerated LV muscle has similar biomechanical properties as native LV myocardium.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Heart Ventricles
Myocardial Infarction
lcsh:Medicine
Mechanical properties
030204 cardiovascular system & hematology
Anterior Descending Coronary Artery
Article
03 medical and health sciences
Mice
0302 clinical medicine
Internal medicine
medicine
Animals
Regeneration
Myocytes, Cardiac
Myocardial infarction
lcsh:Science
Cell Proliferation
Multidisciplinary
Ejection fraction
Ventricular Remodeling
business.industry
Regeneration (biology)
Myocardium
lcsh:R
Sham surgery
Cardiac muscle
Heart
medicine.disease
Biomechanical Phenomena
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
Animals, Newborn
Echocardiography
Cardiology
lcsh:Q
Female
Cardiac regeneration
Collagen
Stress, Mechanical
business
Ligation
Ex vivo
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....ba22033adc731e4b17977126c1f8e588