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Amyloid-related imaging abnormalities from trials of solanezumab for Alzheimer's disease
- Source :
- Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
- Publisher :
- Eli Lilly and Company. Published by Elsevier Inc. on behalf of the Alzheimers Association.
-
Abstract
- Introduction Solanezumab, a humanized monoclonal antibody that binds soluble amyloid beta peptide, is being developed for treatment of Alzheimer's disease (AD). Methods Patients (n = 2042) with mild and moderate AD were randomized 1:1 to 400-mg solanezumab or placebo infusion every 4 weeks for 80 weeks and 1457 patients entered an open-label extension. Magnetic resonance imaging scans monitored for amyloid-related imaging abnormalities-edema/effusion (ARIA-E) and amyloid-related imaging abnormalities-hemorrhage/hemosiderin deposition. Results Sixteen patients (solanezumab, n = 11; placebo, n = 5) developed ARIA-E during the double-blind phase, and 7 patients developed ARIA-E during the open-label extension as of July 31, 2014. Unique cases are discussed including solanezumab patients who were given solanezumab, while ARIA-E was present and a patient who developed ARIA-E during placebo treatment and again during solanezumab treatment. Discussion Asymptomatic ARIA-E was detected in solanezumab-treated and placebo-treated AD patients. ARIA-E occurs infrequently during solanezumab and placebo treatments but may occur repeatedly in some patients.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Pathology
animal structures
Amyloid
Amyloid beta
Neuroimaging
Placebo
Asymptomatic
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Clinical trials
Internal medicine
Amyloid-related imaging abnormalities
Medicine
Solanezumab
medicine.diagnostic_test
biology
business.industry
Magnetic resonance imaging
Alzheimer's disease
Clinical trial
Psychiatry and Mental health
030104 developmental biology
Effusion
biology.protein
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23528729
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
- Accession number :
- edsair.doi.dedup.....ba0a9f2300308ab4906f23a3e4cd5563
- Full Text :
- https://doi.org/10.1016/j.dadm.2016.02.004