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Does mitochondrial fusion require transmembrane potential?
Does mitochondrial fusion require transmembrane potential?
- Source :
- Biochemistry (Moscow). 80:549-558
- Publication Year :
- 2015
- Publisher :
- Pleiades Publishing Ltd, 2015.
-
Abstract
- Dissipation of transmembrane potential inhibits mitochondrial fusion and thus prevents reintegration of damaged mitochondria into the mitochondrial network. Consequently, damaged mitochondria are removed by autophagy. Does transmembrane potential directly regulate the mitochondrial fusion machinery? It was shown that inhibition of ATP-synthase induces fragmentation of mitochondria while preserving transmembrane potential. Moreover, mitochondria of the yeast Saccharomyces cerevisiae retain the ability to fuse even in the absence of transmembrane potential. Metazoan mitochondria in some cases retain ability to fuse for a short period even in a depolarized state. It also seems unlikely that transmembrane potential-based regulation of mitochondrial fusion would prevent reintegration of mitochondria with damaged ATP-synthase into the mitochondrial network. Such reintegration could lead to clonal expansion of mtDNAs harboring deleterious mutations in ATP synthase. We speculate that transmembrane potential is not directly involved in regulation of mitochondrial fusion but affects mitochondrial NTP/NDP ratio, which in turn regulates their fusion.
- Subjects :
- Membrane Potential, Mitochondrial
Mitochondrial DNA
Saccharomyces cerevisiae Proteins
biology
ATP synthase
Saccharomyces cerevisiae
General Medicine
Mitochondrion
Mitochondrial carrier
Mitochondrial Dynamics
Biochemistry
Mitochondria
Cell biology
Mitochondrial Proteins
Mitochondrial membrane transport protein
mitochondrial fusion
Mitochondrial Membranes
biology.protein
Mitochondrial fission
ATP–ADP translocase
Subjects
Details
- ISSN :
- 16083040 and 00062979
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Biochemistry (Moscow)
- Accession number :
- edsair.doi.dedup.....b9ecf0060430abbd1e36d2ffd98e3dfe
- Full Text :
- https://doi.org/10.1134/s0006297915050053