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In vitro and in vivo evaluation of a moisture treatment cream containing three critical elements of natural skin moisturization
- Source :
- Journal of Cosmetic Dermatology
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Objectives To evaluate skin barrier and hydration effects of a new rebalancing moisture treatment (TRMT) and to assess efficacy and tolerability in subjects with photodamaged skin. Methods In an epidermal skin model, tissues (n = 5/group) were topically treated with 25 µL of TRMT, 25 µL of a market‐leading moisturizer (MLM), or untreated for 60 minutes. Hydration was measured at 0, 15, and 30 minutes. Tissues were harvested for gene expression analysis of markers associated with skin barrier and hydration: Claudin (CLD), Aquaporin (AQP), Hyaluronic Acid Syntheses (HAS), and Hyaluronidase (HYAL). A clinical study evaluated twice‐daily application of TRMT, assessing changes in fine lines/wrinkles, brightness, texture, erythema, and tolerability from baseline through week 8. Hydration was measured using electrical impedance. Results TRMT and MLM demonstrated significant increases in hydration vs untreated tissue at each timepoint (P
- Subjects :
- Adult
Male
Skin Care Articles
Erythema
medicine.medical_treatment
Skin Cream
Dermatology
Drug Administration Schedule
Tissue Culture Techniques
Andrology
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cosmeceuticals
Hyaluronidase
In vivo
photoaging of the skin
Hyaluronic acid
medicine
Humans
Rejuvenation
skin barrier
Aged
integumentary system
Chemistry
Original Contribution
cosmeceutical
Middle Aged
Water Loss, Insensible
In vitro
Skin Aging
moisturizing
Treatment Outcome
Tolerability
030220 oncology & carcinogenesis
Female
Epidermis
medicine.symptom
Moisturizer
Cosmeceutical
hydration
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 14732165 and 14732130
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Cosmetic Dermatology
- Accession number :
- edsair.doi.dedup.....b9d1ae67d2071b9259c2b9b949b97402