Back to Search
Start Over
Prospective association between major depressive disorder and leukocyte telomere length over two years
- Source :
- Psychoneuroendocrinology. 90
- Publication Year :
- 2017
-
Abstract
- Background Reduced leukocyte telomere length (LTL) has been found to be associated with multiple common age-related diseases, including heart disease, diabetes, and cancer. A link has also been suggested between shortened LTL and major depressive disorder (MDD), suggesting that MDD may be a disease of accelerated aging. This prospective, longitudinal study examined the association between depression diagnosis at baseline and change in LTL over two years in a well-characterized sample of N = 117 adults with or without MDD at baseline, using rigorous entry criteria. Methods Participants aged 18–70 were assessed with validated instruments by trained, doctoral-level clinician raters at baseline and at two-year follow-up, and blood samples were obtained at both visits. LTL was assayed under identical methods using quantitative polymerase chain reaction (qPCR). The effect of an MDD diagnosis at baseline on change in LTL over two years was examined via hierarchical mixed models, which included potential confounders. Results Individuals with MDD at baseline had greater LTL shortening over two years than individuals without MDD (p = 0.03), even after controlling for differences in age, sex, and body mass index (BMI). In the sub-sample of individuals with MDD diagnoses at baseline, no significant associations between LTL change and symptom severity or duration were found. Conclusion A baseline diagnosis of MDD prospectively predicted LTL shortening over two years. Our results provide further support for MDD as a disease associated with accelerated aging in a well-characterized sample using validated, clinician-rated measures.
- Subjects :
- Adult
Male
medicine.medical_specialty
Longitudinal study
Heart disease
Endocrinology, Diabetes and Metabolism
Disease
behavioral disciplines and activities
Article
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
mental disorders
medicine
Leukocytes
Humans
Prospective Studies
Biological Psychiatry
Depression (differential diagnoses)
Telomere Shortening
Aged
Depressive Disorder, Major
Endocrine and Autonomic Systems
business.industry
Depression
Confounding
Middle Aged
Telomere
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Major depressive disorder
Anxiety
Female
medicine.symptom
business
Body mass index
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 18733360
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Psychoneuroendocrinology
- Accession number :
- edsair.doi.dedup.....b9d1848dee7d1bf4c1ad2ac0aa8655d3