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Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma
- Source :
- Clinical Otolaryngology. 45:221-230
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Objectives To investigate the prognostic values of preoperative platelet-to-lymphocyte ratio (PLR) and platelet-related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC). Methods The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment haematological parameters were categorised into two groups based on the result of X-tile, and several variates were assessed using chi-square test, Kaplan-Meier method, Cox univariate and multivariate analysis. Results The optimal cut-off points of 171.4 for PLR, 260 × 109 /L for platelet, 10.4 fL for mean platelet volume (MPV) and 16.5% for platelet distribution width were defined. The haematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion were statistically significant in OS and DFS analyses (P 171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P Conclusions The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.
- Subjects :
- Blood Platelets
Male
medicine.medical_specialty
Multivariate analysis
Lymphocyte
Gastroenterology
Metastasis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Platelet
Lymphocyte Count
Lymphocytes
Mean platelet volume
030223 otorhinolaryngology
Internal jugular vein
Neoplasm Staging
Retrospective Studies
Platelet Count
Squamous Cell Carcinoma of Head and Neck
business.industry
Platelet Distribution Width
Middle Aged
Prognosis
medicine.disease
Otorhinolaryngologic Surgical Procedures
body regions
medicine.anatomical_structure
Otorhinolaryngology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Hypopharyngeal squamous cell carcinoma
Preoperative Period
Female
business
Subjects
Details
- ISSN :
- 17494486 and 17494478
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Clinical Otolaryngology
- Accession number :
- edsair.doi.dedup.....b9c9f5119cc5fcf1dfa491df1ae29cde