Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Objectives To investigate the prognostic values of preoperative platelet-to-lymphocyte ratio (PLR) and platelet-related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC). Methods The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment haematological parameters were categorised into two groups based on the result of X-tile, and several variates were assessed using chi-square test, Kaplan-Meier method, Cox univariate and multivariate analysis. Results The optimal cut-off points of 171.4 for PLR, 260 × 109 /L for platelet, 10.4 fL for mean platelet volume (MPV) and 16.5% for platelet distribution width were defined. The haematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion were statistically significant in OS and DFS analyses (P 171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P Conclusions The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.