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Assessment of intramyocardial hemorrhage with dark-blood T2*-weighted cardiovascular magnetic resonance
- Source :
- Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-15 (2021), Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, vol 23, iss 1, Journal of Cardiovascular Magnetic Resonance
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Intramyocardial hemorrhage (IMH) within myocardial infarction (MI) is associated with major adverse cardiovascular events. Bright-blood T2*-based cardiovascular magnetic resonance (CMR) has emerged as the reference standard for non-invasive IMH detection. Despite this, the dark-blood T2*-based CMR is becoming interchangeably used with bright-blood T2*-weighted CMR in both clinical and preclinical settings for IMH detection. To date however, the relative merits of dark-blood T2*-weighted with respect to bright-blood T2*-weighted CMR for IMH characterization has not been studied. We investigated the diagnostic capacity of dark-blood T2*-weighted CMR against bright-blood T2*-weighted CMR for IMH characterization in clinical and preclinical settings. Materials and methods Hemorrhagic MI patients (n = 20) and canines (n = 11) were imaged in the acute and chronic phases at 1.5 and 3 T with dark- and bright-blood T2*-weighted CMR. Imaging characteristics (Relative signal-to-noise (SNR), Relative contrast-to-noise (CNR), IMH Extent) and diagnostic performance (sensitivity, specificity, accuracy, area-under-the-curve, and inter-observer variability) of dark-blood T2*-weighted CMR for IMH characterization were assessed relative to bright-blood T2*-weighted CMR. Results At both clinical and preclinical settings, compared to bright-blood T2*-weighted CMR, dark-blood T2*-weighted images had significantly lower SNR, CNR and reduced IMH extent (all p p Conclusion While IMH can be visible on dark-blood T2*-weighted CMR, the overall conspicuity of IMH is significantly reduced compared to that observed in bright-blood T2*-weighted images, across infarct age in clinical and preclinical settings at 1.5 and 3 T. Hence, bright-blood T2*-weighted CMR would be preferable for clinical use since dark-blood T2*-weighted CMR carries the potential to misclassify hemorrhagic MIs as non-hemorrhagic MIs.
- Subjects :
- Magnetic Resonance Spectroscopy
genetic structures
Dark-blood T2
Myocardial Infarction
030204 cardiovascular system & hematology
Cardiorespiratory Medicine and Haematology
Cardiovascular
030218 nuclear medicine & medical imaging
0302 clinical medicine
Myocardial infarction
screening and diagnosis
Radiological and Ultrasound Technology
medicine.diagnostic_test
Magnetic Resonance Imaging
Detection
Nuclear Medicine & Medical Imaging
Intramyocardial hemorrhage
Cardiology
cardiovascular system
Bright-blood T2
Biomedical Imaging
Cardiology and Cardiovascular Medicine
T2 weighted
4.2 Evaluation of markers and technologies
circulatory and respiratory physiology
medicine.medical_specialty
T2*MRI
Hemorrhage
T2* MRI
03 medical and health sciences
Dogs
Predictive Value of Tests
Internal medicine
medicine
Animals
Humans
Diseases of the circulatory (Cardiovascular) system
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
Reference standards
Angiology
business.industry
Research
Myocardium
Magnetic resonance imaging
medicine.disease
4.1 Discovery and preclinical testing of markers and technologies
RC666-701
Dark blood
sense organs
business
Subjects
Details
- Language :
- English
- Volume :
- 23
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Magnetic Resonance
- Accession number :
- edsair.doi.dedup.....b9c882496f4c59e67e6d76d515cede9f