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Molecular characterization of kidney cancer
- Source :
- Cancer. 118:2394-2402
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- BACKGROUND: Molecular profiling of renal cell carcinomas (RCCs) may improve the distinction between oncocytoma and malignant RCC subtypes and aid in early detection of metastasis. The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL-1, HYAL-2, HYAL-3, HYAL-4, PH20, HYAL-P1), and HA receptors (CD44s, CD44v, RHAMM). HA family members promote tumor growth and metastasis. The authors evaluated the expression of HA family members in kidney specimens. METHODS: By using quantitative polymerase chain reaction, mRNA levels of 12 HA family members were measured in tumor specimens obtained from 86 consecutive patients undergoing nephrectomy; 80 of them also provided normal specimens. Mean and median follow-up were 15.2 ± 8.8 and 13.8 months. RCC specimens included clear cell RCC: 65; papillary: 10; chromophobe: 5; oncocytoma: 6; metastasis positive: 17. RESULTS: Median HAS1, CD44s, and RHAMM transcript levels were elevated 3- to 25-fold in clear cell RCC and papillary and chromophobe tumors when compared with normal tissues. HYAL-4, CD44s, and RHAMM levels were elevated 4- to 12-fold in clear cell RCC and papillary tumors when compared with oncocytomas; only HYAL-4 levels distinguished between chromophobe and oncocytoma (P = .009). CD44s and RHAMM levels were significantly higher in tumors
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
medicine.medical_treatment
Chromophobe cell
Kidney
urologic and male genital diseases
Sensitivity and Specificity
Article
Metastasis
chemistry.chemical_compound
Renal cell carcinoma
Hyaluronic acid
Biomarkers, Tumor
medicine
Adenoma, Oxyphilic
Humans
Oncocytoma
Hyaluronic Acid
Neoplasm Metastasis
Carcinoma, Renal Cell
Aged
Aged, 80 and over
Extracellular Matrix Proteins
business.industry
Gene Expression Profiling
Middle Aged
Prognosis
medicine.disease
Kidney Neoplasms
Nephrectomy
Hyaluronan Receptors
Oncology
chemistry
Female
business
Kidney cancer
Clear cell
Subjects
Details
- ISSN :
- 0008543X
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi.dedup.....b9c2582845c2db3e73da3cfd1f66e769