Comparison of Cognitive Effects of Lamotrigine and Oxcarbazepine in Epilepsy Patients

Background and Purpose: This s tud y c o mp a re d the c o g n itive e ffec ts o f 1 ye a r o f tre a tmen t with la mo trig in e (LTG) a nd o xc arb a ze pi n e (OXC) in e pi le psy p at ient s . Met h ods: This r et ro spect ive s tu dy in ve st ig at e d 60 e pi le psy p at ie nt s u nd ergoi n g n europsy c ho lo gi c al test s who were e ither n ew ly dia gnosed o r u nt re at e d in the p recedi n g 6 mo n ths . The c o g n itive fu n c tio n in 30 p a tie n ts re c e ivin g LTG mo not he rapy a nd 30 a ge- ma tc he d p at ie nt s r ecei vin g OXC mo not he ra py wa s c om p ared a fte r 1 year . The neuropsy c ho lo gi c al s cores a t ba sel in e a nd a ll o f the epi lepsy -r el e va nt va ria bles e xc ept s ei zu re typ e did n ot d iffer be twe en the g ro u p s . The mea n d a ily d o s a g es o f LTG a n d OXC a t 1 ye ar we re 93 mg a nd 825 mg , re spect ively. Resul t s: The p o s ttre a tmen t lis t-le a r n in g p er fo rma n c e wa s bette r in the LTG g roup tha n in the OXC g roup (p