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Usefulness of MRI targeted prostate biopsy for detecting clinically significant prostate cancer in men with low prostate-specific antigen levels
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
-
Abstract
- We aimed to evaluate the detection rates of prostate cancer (PCa) and clinically significant PCa (csPCa) using magnetic resonance imaging-targeted biopsy (MRI-TBx) in men with low prostate-specific antigen (PSA) levels (2.5–4.0 ng/mL). Clinicopathologic data of 5502 men with PSA levels of 2.5–10.0 ng/mL who underwent transrectal ultrasound-guided biopsy (TRUS-Bx) or MRI-TBx were reviewed. Participants were divided into four groups: LP-T [low PSA (2.5–4.0 ng/mL) and TRUS-Bx, n = 2018], LP-M (low PSA and MRI-TBx, n = 186), HP-T [high PSA (4.0–10.0 ng/mL) and TRUS-Bx, n = 2953], and HP-M (high PSA and MRI-TBx, n = 345). The detection rates of PCa and csPCa between groups were compared, and association of biopsy modality with detection of PCa and csPCa in men with low PSA levels were analyzed. The detection rates of PCa (20.0% vs. 38.2%; P P P = 0.263) and csPCa (32.3% vs. 39.4%; P = 0.103) between the LP-M and HP-M groups. Multivariate analyses revealed that using MRI-TBx could predict the detection of csPCa (odds ratio 2.872; 95% confidence interval 1.996‒4.132; P
- Subjects :
- Image-Guided Biopsy
Male
medicine.medical_specialty
Prostate biopsy
Multivariate analysis
Science
Urology
urologic and male genital diseases
Sensitivity and Specificity
Article
Prostate cancer
Biopsy
Medicine
Humans
Aged
Cancer
Multidisciplinary
medicine.diagnostic_test
business.industry
Prostatic Neoplasms
Magnetic resonance imaging
Odds ratio
Middle Aged
Prostate-Specific Antigen
medicine.disease
Magnetic Resonance Imaging
Confidence interval
Prostate-specific antigen
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....b9b91a046417629011ebe1033dc1bef0