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Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls
- Source :
- Heveltica Chimica Acta, Heveltica Chimica Acta, 2017, 100 (6), pp.e1700101. ⟨10.1002/hlca.201700101⟩
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- International audience; Hyperpolarization by dynamic nuclear polarization relies on the microwave irradiation of paramagnetic radicals dispersed in molecular glasses to enhance the nuclear magnetic resonance (NMR) signals of target molecules. However, magnetic or chemical interactions between the radicals and the target molecules can lead to attenuation of the NMR signal through paramagnetic quenching and/or radical decomposition. Here we describe polarizing materials incorporating nitroxide radicals within the walls of the solids to minimize interactions between the radicals and the solute. These materials can hyperpolarize pure pyruvic acid, a particularly important substrate of clinical interest, while nitroxide radicals cannot be used, even when incorporated in the pores of silica, because of reactions between pyruvic acid and the radicals. The properties of these materials can be engineered by tuning the composition of the wall by introducing organic functionalities.
- Subjects :
- Nitroxide mediated radical polymerization
Radical
Magic angle spinning dynamic nuclear polarization
Inorganic chemistry
Hybrid organic-inorganic materials
Chemical interaction
010402 general chemistry
Photochemistry
01 natural sciences
Biochemistry
Catalysis
Inorganic Chemistry
Paramagnetism
Molecular glasses
Drug Discovery
[CHIM]Chemical Sciences
Molecule
Physics::Chemical Physics
Physical and Theoretical Chemistry
[CHIM.ORGA]Chemical Sciences/Organic chemistry
010405 organic chemistry
Chemistry
Organic Chemistry
Dissolution dynamic nuclear polarization
0104 chemical sciences
[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry
Microwave irradiation
Mesostructured silica
Subjects
Details
- ISSN :
- 0018019X
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Helvetica Chimica Acta
- Accession number :
- edsair.doi.dedup.....b9b8a51b6c749d6d37660725ee1d9693