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MicroRNA-139 suppresses hepatocellular carcinoma cell proliferation and migration by directly targeting Topoisomerase I
- Publication Year :
- 2018
- Publisher :
- D.A. Spandidos, 2018.
-
Abstract
- microRNAs (miRNAs) have been determined to be associated with cancer progression and metastasis. Mir-139 is located on 11q13.4 and exhibits anti-oncogenic and anti-metastatic activity in human cancers. It is downregulated in various malignant tumor types. In the present study, the potential functions and targets of miR-139 in hepatocellular carcinoma (HCC) were explored. Using a combinational analysis of four miRNA target prediction tools and biological experiments, it was determined that Topoisomerase I (TOP1) is a direct target of miR-139 in HCC. Several traditional topoisomerase inhibitors have demonstrated anticancer activity, but their side effects outnumbered their anticancer potential. The present study determined that overexpression of miR-139 significantly inhibits HCC cell proliferation (P
- Subjects :
- 0301 basic medicine
Cancer Research
Oncogene
biology
medicine.drug_class
Chemistry
Topoisomerase
Cell
Cancer
Articles
Cell cycle
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Oncology
Downregulation and upregulation
030220 oncology & carcinogenesis
microRNA
medicine
Cancer research
biology.protein
Topoisomerase inhibitor
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b9ad8daf1dc6214da92312c2e937d688