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Heat treatment and irradiation reduce anti-bacterial and immune-modulatory properties of bovine colostrum
- Source :
- Journal of Functional Foods, Vol 57, Iss, Pp 182-189 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Colostrum contains bioactive components protecting the newborn intestine against bacteria. It is unclear how to optimize processing conditions with highest product bioactivity. Non-pasteurized (BC00), standard-pasteurized (72 °C-15 s, BC72), gently-pasteurized bovine colostrums without (63 °C-30 min, BC63) and with gamma-irradiation (BC63g) were tested for effects on bacterial growth inhibition (Escherichia coli, Staphylococcus aureus and S. epidermidis), intestinal epithelial cell (IEC) proliferation and cytokine secretion in vitro. Thermal processing decreased endogenous bacteria and IgG levels. All BCs inhibited bacterial growth 1–2 h after inoculation, but only BC00, BC63 and BC63g retained activity after 4–24 h. After 4 h, the activity against S. epidermidis of BC63g was lower than BC00 but still potent when mixed with formula. All BCs stimulated IEC proliferation, with the most pronounced responses for BC00. Only BC00 and BC63 increased IL-8 secretion in lipopolysaccharide-stimulated IECs. Thermal processing reduced bioactivity and combined gentle pasteurization and gamma-irradiation improved BC sterility and bioactivity, relative to standard pasteurization.
- Subjects :
- 0301 basic medicine
Bovine colostrum
Medicine (miscellaneous)
Bacterial growth
Antimicrobial activity
medicine.disease_cause
Microbiology
03 medical and health sciences
0404 agricultural biotechnology
Immune system
parasitic diseases
medicine
Secretion
TX341-641
Escherichia coli
030109 nutrition & dietetics
Nutrition and Dietetics
biology
Chemistry
Nutrition. Foods and food supply
Preterm infants
04 agricultural and veterinary sciences
biology.organism_classification
040401 food science
Staphylococcus aureus
Bacterial growth inhibition
Colostrum
Pasteurization
Cytokine secretion
Bacteria
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....b9aabb3abf610985c80583cbb989279b