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Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis
- Source :
- Cardiovascular drugs and therapy. 36(1)
- Publication Year :
- 2020
-
Abstract
- Cardiac dysfunction can occur as a sequela of a state of prolonged pressure overload and postischemic injury. Flavonoids such as quercetin may be protective against cardiovascular disease. This study aimed to systematically assess the effects of quercetin on cardiac function in pressure overload and postischemia-reperfusion injury in rodents. A systematic search of the literature up to May 2020 was conducted in PubMed, Ovid Medline, EBSCOhost, Scopus, and the Cochrane Library to identify relevant published studies on quercetin and cardiac function using standardized criteria. Meta-analyses were performed on animal studies of pressure overload and ischemia-reperfusion (I/R) injury. The effects of quercetin on cardiac function in both models were qualitatively reported in 14 studies. The effects of quercetin in four pressure-overload model studies involving 73 rodents and eight I/R-injury model studies involving 120 rodents were quantitatively assessed by meta-analysis. Quercetin improved the overall cardiac function in both pressure overload (n = 4 studies, n = 73 rodents; SMD = − 1.50; 95% CI: − 2.66 to − 0.33; P
- Subjects :
- 0301 basic medicine
Cardiac function curve
medicine.medical_specialty
Cardiotonic Agents
Diastole
Myocardial Reperfusion Injury
030204 cardiovascular system & hematology
Cochrane Library
03 medical and health sciences
Mice
Ventricular Dysfunction, Left
0302 clinical medicine
Internal medicine
medicine
Ventricular Pressure
Animals
heterocyclic compounds
Pharmacology (medical)
Pharmacology
Pressure overload
business.industry
Sequela
General Medicine
medicine.disease
Rats
Disease Models, Animal
030104 developmental biology
Meta-analysis
Cardiology
Ventricular pressure
Quercetin
Animal studies
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15737241
- Volume :
- 36
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cardiovascular drugs and therapy
- Accession number :
- edsair.doi.dedup.....b9a58d0b3578e643fd538183e2e908de