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Synchrotron Radiation-Based Reconstruction of the Human Spiral Ganglion: Implications for Cochlear Implantation
- Source :
- Ear & Hearing. 41:173-181
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Objective To three-dimensionally reconstruct Rosenthal's canal (RC) housing the human spiral ganglion (SG) using synchrotron radiation phase-contrast imaging (SR-PCI). Straight cochlear implant electrode arrays were inserted to better comprehend the electro-cochlear interface in cochlear implantation (CI). Design SR-PCI was used to reconstruct the human cochlea with and without cadaveric CI. Twenty-eight cochleae were volume rendered, of which 12 underwent cadaveric CI with a straight electrode via the round window (RW). Data were input into the 3D Slicer software program and anatomical structures were modeled using a threshold paint tool. Results The human RC and SG were reproduced three-dimensionally with artefact-free imaging of electrode arrays. The anatomy of the SG and its relationship to the sensory organ (Corti) and soft and bony structures were assessed. Conclusions SR-PCI and computer-based three-dimensional reconstructions demonstrated the relationships among implanted electrodes, angular insertion depths, and the SG for the first time in intact, unstained, and nondecalcified specimens. This information can be used to assess stimulation strategies and future electrode designs, as well as create place-frequency maps of the SG for optimal stimulation strategies of the human auditory nerve in CI.
- Subjects :
- Materials science
medicine.medical_treatment
Straight electrode
Synchrotron radiation
01 natural sciences
03 medical and health sciences
Speech and Hearing
Percutaneous Coronary Intervention
0302 clinical medicine
Cochlear implant
0103 physical sciences
otorhinolaryngologic diseases
medicine
Humans
030223 otorhinolaryngology
Cochlear implantation
010301 acoustics
Spiral ganglion
Cochlea
Round window
Cochlear Implantation
Electrodes, Implanted
Cochlear Implants
medicine.anatomical_structure
Otorhinolaryngology
sense organs
Spiral Ganglion
Cadaveric spasm
Synchrotrons
Biomedical engineering
Subjects
Details
- ISSN :
- 01960202
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Ear & Hearing
- Accession number :
- edsair.doi.dedup.....b96f9ee4cda4b5f8352e0152d42a61dc