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Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome
- Source :
- American journal of respiratory cell and molecular biology, vol 63, iss 1, Am J Respir Cell Mol Biol
- Publication Year :
- 2020
- Publisher :
- American Thoracic Society, 2020.
-
Abstract
- Recent research on extracellular vesicles (EVs) has provided new insights into pathogenesis and potential therapeutic options for acute respiratory distress syndrome (ARDS). EVs are membrane-bound anuclear structures that carry important intercellular communication mechanisms, allowing targeted transfer of diverse biologic cargo, including protein, mRNA, and microRNA, among several different cell types. In this review, we discuss the important role EVs play in both inducing and attenuating inflammatory lung injury in ARDS as well as in sepsis, the most important clinical cause of ARDS. We discuss the translational challenges that need to be overcome before EVs can also be used as prognostic biomarkers in patients with ARDS and sepsis. We also consider how EVs may provide a platform for novel therapeutics in ARDS.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
ARDS
Messenger
Respiratory System
Clinical Biochemistry
Cell Communication
Acute respiratory distress
Cardiorespiratory Medicine and Haematology
Lung injury
Bioinformatics
Extracellular vesicles
sepsis
Pathogenesis
Sepsis
Extracellular Vesicles
03 medical and health sciences
Rare Diseases
0302 clinical medicine
microRNA
Genetics
medicine
Animals
Humans
In patient
RNA, Messenger
Lung
Molecular Biology
Respiratory Distress Syndrome
business.industry
Inflammatory and immune system
Hematology
Cell Biology
acute respiratory distress syndrome
medicine.disease
MicroRNAs
Translational Review
030104 developmental biology
acute lung injury
030228 respiratory system
RNA
business
Biomarkers
Subjects
Details
- ISSN :
- 15354989 and 10441549
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory Cell and Molecular Biology
- Accession number :
- edsair.doi.dedup.....b96b47768bed9963d72b0aa1f4906e9b