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Investigation of the Acoustic Vaporization Threshold of Lipid-Coated Perfluorobutane Nanodroplets Using Both High-Speed Optical Imaging and Acoustic Methods
- Source :
- Ultrasound in Medicine & Biology. 47:1826-1843
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- A combination of ultrahigh-speed optical imaging (5 × 106 frames/s), B-mode ultrasound and passive cavitation detection was used to study the vaporization process and determine both the acoustic droplet vaporization (ADV) and inertial cavitation (IC) thresholds of phospholipid-coated perfluorobutane nanodroplets (PFB NDs, diameter = 237 ± 16 nm). PFB NDs have not previously been studied with ultrahigh-speed imaging and were observed to form individual microbubbles (1–10 μm) within two to three cycles and subsequently larger bubble clusters (10–50 μm). The ADV and IC thresholds did not statistically significantly differ and decreased with increasing pulse length (20–20,000 cycles), pulse repetition frequency (1–100 Hz), concentration (108–1010 NDs/mL), temperature (20°C–45°C) and decreasing frequency (1.5–0.5 MHz). Overall, the results indicate that at frequencies of 0.5, 1.0 and 1.5 MHz, PFB NDs can be vaporized at moderate peak negative pressures (
- Subjects :
- Pulse repetition frequency
Materials science
Acoustics and Ultrasonics
Biophysics
Analytical chemistry
02 engineering and technology
030218 nuclear medicine & medical imaging
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Vaporization
Radiology, Nuclear Medicine and imaging
Phospholipids
Fluorocarbons
Acoustic droplet vaporization
Radiological and Ultrasound Technology
Perfluorobutane
business.industry
Optical Imaging
Ultrasound
Pulse duration
Acoustics
021001 nanoscience & nanotechnology
chemistry
Cavitation
Microbubbles
Nanoparticles
Volatilization
0210 nano-technology
business
Subjects
Details
- ISSN :
- 03015629
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Ultrasound in Medicine & Biology
- Accession number :
- edsair.doi.dedup.....b96406411364c798e6d79e51d65491c6