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Short‐term changes in left and right systolic function following ferric carboxymaltose: a substudy of the Myocardial‐IRON trial
- Source :
- ESC Heart Failure, Vol 7, Iss 6, Pp 4222-4230 (2020), Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, ESC Heart Failure
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Funding: This work was supported in part by an unrestricted grant from Vifor Pharma and Proyectos de Investigación de la Sección de Insuficiencia Cardiaca 2017 from Sociedad Española de Cardiología. The mechanisms underlying the beneficial effect of ferric carboxymaltose (FCM) in patients with heart failure (HF) and iron deficiency (ID) have not been completely characterized. The Myocardial-IRON trial was a double-blind, randomized trial that evaluated myocardial iron repletion following FCM vs. placebo in 53 patients with HF and ID. In this post hoc analysis, we evaluated whether treatment with FCM was associated with cardiac magnetic resonance changes in left and right ventricular function (LVEF and RVEF, respectively) at different points of systolic dysfunction. We included patients from the Myocardial-IRON trial with left and right ventricular systolic dysfunction (LVSD and RVSD, respectively) at enrolment. Linear mixed regression models were used to evaluate changes at 7 and 30 days on LVEF and RVEF at cardiac magnetic resonance. At enrolment, 27 (50.9%) and 38 (71.7%) patients had LVEF < 40% (LVSD) or
- Subjects :
- medicine.medical_specialty
Myocardial iron
Heart failure
Systolic function
030204 cardiovascular system & hematology
Placebo
FERRIC CARBOXYMALTOSE
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Original Research Articles
Post-hoc analysis
medicine
Diseases of the circulatory (Cardiovascular) system
030212 general & internal medicine
Original Research Article
Ventricular systolic function
Ejection fraction
business.industry
Iron deficiency
medicine.disease
Ferric carboxymaltose
RC666-701
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 20555822
- Volume :
- 7
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- ESC Heart Failure
- Accession number :
- edsair.doi.dedup.....b961ac4af5071d3a90625a501a116fc7