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Involvement of periaqueductal gray area NMDA receptors in endothelin-induced behavioural effects
- Source :
- European Journal of Pharmacology. 250:209-212
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- We investigated the behavioural effects induced by endothelin-1 injected into the lateral-caudal periaqueductal gray matter of freely moving rats. Endothelin-1 induced a dose-dependent longitudinal rolling of the body (barrel rolling) which was prevented by D,L-2-amino-5-phosphonovalerate (2-APV), an N-methyl-D-aspartate (NMDA) receptor antagonist, but not by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a non-NMDA receptor antagonist. This effect, not reproducible with NMDA alone, indicates that the activation of the NMDA receptors in the periaqueductal gray area may be a necessary, but not sufficient, step for the triggering of endothelin-1-induced barrel-rolling behaviour.
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
Motor Activity
Receptors, N-Methyl-D-Aspartate
Periaqueductal gray
Rats, Sprague-Dawley
chemistry.chemical_compound
Quinoxalines
Internal medicine
medicine
Animals
Periaqueductal Gray
2-Amino-5-phosphonovalerate
6-Cyano-7-nitroquinoxaline-2,3-dione
Pharmacology
Behavior, Animal
Dose-Response Relationship, Drug
Endothelins
Receptor antagonist
Endothelin 1
Rats
Endocrinology
nervous system
Mechanism of action
chemistry
CNQX
NMDA receptor
medicine.symptom
Endothelin receptor
Neuroscience
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 250
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....b95ac6e96969ce28091526f4821e934b