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Julichrome Q6 Glucuronide, a Monomeric Subunit of the Julimycin B-I Complex from a Terrestrial Streptomyces sp
- Source :
- Journal of Natural Products. 70:1545-1550
- Publication Year :
- 2007
- Publisher :
- American Chemical Society (ACS), 2007.
-
Abstract
- The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide ( 9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q 1.2 ( 7a), Q 1.5 ( 7b), and Q 3.5 ( 8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol ( 6a) and N-phenyl-beta-naphthylamine ( 10). The isomeric N-phenyl-alpha-naphthylamine ( 11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.
- Subjects :
- Stereochemistry
Protein subunit
Pharmaceutical Science
Glucuronates
Marine Biology
Chlorella
Factor VIIa
Microbial Sensitivity Tests
Naphthalenes
010402 general chemistry
01 natural sciences
Streptomyces
Analytical Chemistry
chemistry.chemical_compound
2-Naphthylamine
Candida albicans
Drug Discovery
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
Bacteria
Molecular Structure
biology
010405 organic chemistry
Organic Chemistry
biology.organism_classification
Recombinant Proteins
0104 chemical sciences
1-Naphthylamine
Monomer
Complementary and alternative medicine
chemistry
Molecular Medicine
Drug Screening Assays, Antitumor
Glucuronide
Two-dimensional nuclear magnetic resonance spectroscopy
Nosiheptide
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....b9577a7c6029adff2402750d2fff2fd3