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Asymmetric Total Synthesis of Nannocystin A
- Source :
- The Journal of organic chemistry. 82(17)
- Publication Year :
- 2017
-
Abstract
- Nannocystin A is a novel 21-membered macrolactone isolated from myxobacterium Nanocystis sp. It is a potent elongation factor 1 inhibitor and inhibits cancer cell line growth at nanomolar concentrations. In this work, a concise asymmetric total synthesis of nannocystin A has been developed, which features Sharpless epoxidation, Stille coupling, and final macrolactamization.
- Subjects :
- Sharpless epoxidation
Macrocyclic Compounds
010405 organic chemistry
Stereochemistry
Chemistry
Organic Chemistry
Molecular Conformation
Total synthesis
010402 general chemistry
01 natural sciences
Eukaryotic translation elongation factor 1 alpha 1
0104 chemical sciences
Stille reaction
Cancer cell lines
Subjects
Details
- ISSN :
- 15206904
- Volume :
- 82
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- The Journal of organic chemistry
- Accession number :
- edsair.doi.dedup.....b9569ab4ceaef0f3d2b48548de64668d