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Organometallic-based antibacterial and antifungal compounds: transition metal complexes of 1,1′-diacetylferrocene-derived thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone
- Source :
- Journal of Enzyme Inhibition and Medicinal Chemistry. 20:81-89
- Publication Year :
- 2005
- Publisher :
- Informa UK Limited, 2005.
-
Abstract
- Organometallic-based, 1,1'-diacetylferrocene-derived antibacterial and antifungal thiocarbohydrazone, carbohydrazone, thiosemicarbazone and semicarbazone have been prepared by condensing equimolar amount of 1,1'-diacetylferrocene with thiocarbohydrazide, carbohydrazide thiosemicarbazide and semicarbazide, respectively. These were used as ligands for the preparation of their cobalt (II), copper (II), nickel (II) and zinc (II) metal complexes. All the synthesized ligands and their complexes were characterized by IR, NMR, elemental analyses, molar conductances, magnetic moments and electronic spectral data. These synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus subtillis, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi, and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar-well diffusion method. All the compounds showed good antibacterial and antifungal activity which increased on coordination with the metal ions thus, introducing a novel class of organometallic-based antibacterial and antifungal agents.
- Subjects :
- Antifungal Agents
Metallocenes
Metal ions in aqueous solution
chemistry.chemical_element
Microbial Sensitivity Tests
Zinc
Carbohydrazide
Ligands
chemistry.chemical_compound
Nickel
Drug Discovery
Organometallic Compounds
Organic chemistry
Ferrous Compounds
Candida albicans
Semicarbazone
Pharmacology
Thiocarbohydrazide
Semicarbazide
biology
Chemistry
Hydrazones
Cobalt
General Medicine
biology.organism_classification
Anti-Bacterial Agents
Antibacterial activity
Copper
Nuclear chemistry
Subjects
Details
- ISSN :
- 14756374 and 14756366
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....b953088fbccb5ac39d00986e46a52bf5