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Amelanotic Malignant Melanoma of the Male Urethra: A Potential Diagnostic Pitfall
- Source :
- International Journal of Surgical Pathology. 28:510-513
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- A rare disease in an unusual site can closely mimic a typical presentation of a common disease, sometimes with devastating consequences. We present a case of primary amelanotic malignant melanoma of the urethra in a male, with clinical and histological characteristics that could have led to a mistaken diagnosis of high-grade urothelial carcinoma. Amelanotic mucosal melanoma should be suspected in all cases of high-grade mucosal tumors with practically any appearance (epithelioid, sarcomatoid, anaplastic, mixed). Morphological hints pointing toward melanoma—such as the presence of sparse melanin pigment or melanoma in situ—should be sought, and if absent, an immunohistochemical panel comprising S100 and HMB45 should be performed.
- Subjects :
- Male
Pathology
medicine.medical_specialty
amelanotic melanoma
diagnostic pitfall
mucosal melanoma
urethral melanoma
030232 urology & nephrology
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Amelanotic melanoma
Urethral Neoplasms
integumentary system
business.industry
Melanoma
Mucosal melanoma
Melanoma, Amelanotic
Middle Aged
medicine.disease
Male urethra
Urethra
medicine.anatomical_structure
030220 oncology & carcinogenesis
Immunohistochemistry
Surgery
Anatomy
Melanin pigment
business
Rare disease
Subjects
Details
- ISSN :
- 19402465 and 10668969
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- International Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....b951c535034269a4c3a6bc3fca021fd9