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Methylation biomarkers with discriminating ability are potential therapeutic targets in lung adenocarcinoma
- Source :
- Epigenomics. 14:469-480
- Publication Year :
- 2022
- Publisher :
- Future Medicine Ltd, 2022.
-
Abstract
- Aims: Given the reversibility of methylation, biomarkers with discriminating ability are of great interest for targeted therapeutic sites. Materials & methods: Methylation array data of 461 lung adenocarcinoma (LUAD) patients comprising of 458 tumor and 32 LUAD paracancerous samples were compared using partial least squares discrimination analysis and receiver operating characteristics analysis. Results: A six-DNA methylation signature (corresponding to five genes) was found to significantly discriminate normal and LUAD samples. Kyoto Encyclopedia of Genes and Genomes analysis indicated enrichment of methylation sites in the Wnt pathway in LUAD compared with controls. Conclusion: This six-DNA methylation signature demonstrated potential as a novel biomarker for diagnosis and therapeutic targets. Further, inhibition of Wnt signaling pathway may be an important step in LUAD progression.
- Subjects :
- Cancer Research
Lung Neoplasms
Wnt signaling pathway
Notch signaling pathway
Adenocarcinoma of Lung
Methylation
DNA Methylation
Biology
medicine.disease
Gene Expression Regulation, Neoplastic
DNA methylation
Biomarkers, Tumor
Genetics
medicine
Cancer research
Humans
Adenocarcinoma
Biomarker (medicine)
KEGG
Wnt Signaling Pathway
Gene
Subjects
Details
- ISSN :
- 1750192X and 17501911
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Epigenomics
- Accession number :
- edsair.doi.dedup.....b93c56bfc7df5d73a3e0b0fe30e696fc