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Dietary Nucleotides Supplementation Improves the Intestinal Development and Immune Function of Neonates with Intra-Uterine Growth Restriction in a Pig Model
- Source :
- PLoS ONE, Vol 11, Iss 6, p e0157314 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- The current study aimed to determine whether dietary nucleotides supplementation could improve growth performance, intestinal development and immune function of intra-uterine growth restricted (IUGR) neonate using pig as animal model. A total of 14 pairs of normal birth weight (NBW) and IUGR piglets (7 days old) were randomly assigned to receive a milk-based control diet (CON diet) or diet supplemented with nucleotides (NT diet) for a period of 21 days. Blood samples, intestinal tissues and digesta were collected at necropsy and analyzed for morphology, digestive enzyme activities, microbial populations, peripheral immune cells, expression of intestinal innate immunity and barrier-related genes and proteins. Compared with NBW piglets, IUGR piglets had significantly lower average daily dry matter intake and body weight gain (P
- Subjects :
- 0301 basic medicine
Male
Swine
Physiology
medicine.medical_treatment
Interleukin-1beta
Gene Expression
lcsh:Medicine
Weight Gain
Immune Receptors
Biochemistry
Jejunum
White Blood Cells
Pig Models
Animal Cells
Medicine and Health Sciences
Lymphocytes
lcsh:Science
Toll-like Receptors
Mammals
Multidisciplinary
Fetal Growth Retardation
Immune System Proteins
Nucleotides
Reverse Transcriptase Polymerase Chain Reaction
Lactase
Agriculture
Animal Models
Intestines
medicine.anatomical_structure
Physiological Parameters
Vertebrates
Animal Nutritional Physiological Phenomena
Female
medicine.symptom
Anatomy
Cellular Types
Research Article
Signal Transduction
medicine.medical_specialty
Livestock
Immune Cells
Blotting, Western
Immunology
Ileum
Biology
Research and Analysis Methods
Feed conversion ratio
03 medical and health sciences
Immune system
Model Organisms
Internal medicine
medicine
Animals
Nutrition
030109 nutrition & dietetics
Tight Junction Proteins
Blood Cells
Body Weight
lcsh:R
Organisms
Biology and Life Sciences
Proteins
Cell Biology
Gastrointestinal Microbiome
Diet
Gastrointestinal Tract
Disease Models, Animal
030104 developmental biology
Endocrinology
Animals, Newborn
Dietary Supplements
Amniotes
Duodenum
lcsh:Q
Maltase
Weight gain
Digestive System
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....b931e0b92a38b040fab1ac54832a0a78